Chemical Structure : Cl-NIO
CAS No.:
1606129-72-9
Cl-NIO
Catalog No.: PC-49751Not For Human Use, Lab Use Only.
Cl-NIO is a potent, selective inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1) with Ki of 1.3 uM, > 500-fold selectivity against arginase and endothelial nitric oxide synthase.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Cl-NIO is a potent, selective inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1) with Ki of 1.3 uM, > 500-fold selectivity against arginase and endothelial nitric oxide synthase.
Cl-NIO displays cellular inhibition of DDAH-1 artificially expressed within cultured HEK293T cells with IC50 of 6.6 uM.
Cl-NIO inhibits DDAH-1 within cultured human cells and leads to downstream inhibition of nitric oxide biosynthesis.
Cl-NIO treatment (10 uM) resulted in a concentration-dependent decrease in NO2− + NO3− levels in A375 melanoma cell line, which reflects decreased nitric oxide production.
Cl-NIO is a suitable tool for studies of methylarginine-mediated regulation of nitric oxide production and as a potential therapeutic lead for a variety of indications with elevated nitric oxide levels.
Physicochemical Properties
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M.Wt
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207.66
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Formula
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C7H14ClN3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-2-amino-5-(2-chloroacetimidamido)pentanoic acid
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References
1. Yun Wang, et al. ChemMedChem. 2014 Apr;9(4):792-7.
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