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Chemical Structure : Cl-amidine TFA
CAS No.: 1043444-18-3
Catalog No.: PC-22866Not For Human Use, Lab Use Only.
Cl-amidine TFA is a potent, irreversible, orall active inhibitor of protein arginine deiminases (PADs) with IC50 of 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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Cl-amidine TFA is a potent, irreversible, orall active inhibitor of protein arginine deiminases (PADs) with IC50 of 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4, respectively.
Cl-amidine is cytotoxic to HL-60, MCF-7, and HT-29 cancer cells (IC50s = 0.25, 0.05, and 1 μM, respectively).
Cl-amidine (50 mg/kg) reduces ex vivo extracellular neutrophil extracellular trap (NET) formation and increases survival in a mouse model of sepsis induced by cecal ligation and puncture (CLP).
Cl-amidine also decreases the citrulline content in serum and joints and reduces the development of IgG autoantibodies in a mouse model of collagen-induced arthritis in a dose-dependent manner.
| M.Wt | 424.81 | |
| Formula | C16H20ClF3N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2S)-5-(2-Chloroethanimidamido)-2-(phenylformamido)pentanamide trifluoroacetic acid salt |
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1. Yuan Luo, et al. Biochemistry. 2006 Oct 3; 45(39): 11727–11736.
2. Witalison EE, et al. Oncotarget. 2015 Nov 3;6(34):36053-62.
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