Claudin 5 binder CL5B | CLDN5 binder | Probechem Biochemicals

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Chemical Structure : Claudin 5 binder CL5B

Claudin 5 binder CL5B (CLDN5 binder)

Catalog No.: PC-25817Not For Human Use, Lab Use Only.

Claudin 5 binder CL5B is a small molecule binder of Claudin 5 (CLDN5), binds directly to hCLDN5 with KD of 31.7 uM, opens the blood-brain barrier and safely enhances brain drug delivery.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Claudin 5 binder CL5B is a small molecule binder of Claudin 5 (CLDN5), binds directly to hCLDN5 with KD of 31.7 uM, opens the blood-brain barrier and safely enhances brain drug delivery.
CL5B enhances endothelial permeability and promotes small-molecule permeation.
CL5B reversibly enhances endothelial permeability by altering CLDN5 localization.
CL5B regulates mouse BBB and promotes drug delivery to the brain.
CL5B-mediated methylscopolamine delivery to the brain alleviates epilepsy in an experimental mouse model.

Physicochemical Properties

M.Wt	269.34
Formula	C17H19NO2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-(4-isopropylphenyl)-3-(5-methylfuran-2-yl)acrylamide

References

1. Inoue S, et al. J Control Release. 2025 Oct 11:114314.

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