Catalog No.: PC-25817Not For Human Use, Lab Use Only.
Claudin 5 binder CL5B is a small molecule binder of Claudin 5 (CLDN5), binds directly to hCLDN5 with KD of 31.7 uM, opens the blood-brain barrier and safely enhances brain drug delivery.
Claudin 5 binder CL5B is a small molecule binder of Claudin 5 (CLDN5), binds directly to hCLDN5 with KD of 31.7 uM, opens the blood-brain barrier and safely enhances brain drug delivery.
CL5B enhances endothelial permeability and promotes small-molecule permeation.
CL5B reversibly enhances endothelial permeability by altering CLDN5 localization.
CL5B regulates mouse BBB and promotes drug delivery to the brain.
CL5B-mediated methylscopolamine delivery to the brain alleviates epilepsy in an experimental mouse model.
