Clocinizine

Chemical Structure : Clocinizine

Catalog No.: PC-25438Not For Human Use, Lab Use Only.

Clocinizine is a chlorinated analogue of cinnarizine, shows potent antischistosomal activity against both male and female parasites with EC50 and EC90 of 4.6 uM and 5.9 uM respectively.

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Biological Activity

Clocinizine is a chlorinated analogue of cinnarizine, shows potent antischistosomal activity against both male and female parasites with EC50 and EC90 of 4.6 uM and 5.9 uM respectively.
Clocinizine demonstrated a clear time- and concentration-dependent effect on both male and female worms.
Clocinizine (400 mg/kg) significantly reduced the total worm burden by 86.4% (P < 0.001) in animal model infected with S. mansoni.

Physicochemical Properties

M.Wt	402.97
Formula	C26H27ClN2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((4-chlorophenyl)(phenyl)methyl)-4-cinnamylpiperazine

References

1. Castro T, et al. Sci Rep. 2025 Aug 21;15(1):30816.

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Clocinizine

Biological Activity

Physicochemical Properties

References

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