Chemical Structure : Compound 212-148
CAS No.:
Compound 212-148
Catalog No.: PC-21419Not For Human Use, Lab Use Only.
Compound 212-148 a bispecific, dual inhibitor of both TMPRSS2 and cysteine proteases cathepsin L/B (CTSL/CTSB) with IC50 of 1.38 uM and 2.13/64.07 nM, respectively, demonstrates antiviral activity against various SARS-CoV-2 variants.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Compound 212-148 a bispecific, dual inhibitor of both TMPRSS2 and cysteine proteases cathepsin L/B (CTSL/CTSB) with IC50 of 1.38 uM and 2.13/64.07 nM, respectively, demonstrates antiviral activity against various SARS-CoV-2 variants.
Compound 212-148 simultaneously blocks TMPRSS2- and CTSL/CTSB-mediated viral entry pathways, exhibits synergistic antiviral activity against SARS-CoV-2.
Compound 212-148 inhibits the entry of pseudotyped SARS-CoV-2 Omicron variants BA.2.12.1 and BA.4 & BA.5 with a similar EC50 value of 0.4 nM in Huh-7 cells.
Compound 212-148 inhibits the SARS-CoV-2 Omicron BA.2 and Delta variants infection with EC50 values of 64.4 and 235.2 nM, respectively, in Calu-3 cells.
Physicochemical Properties
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M.Wt
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765.93
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Formula
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C41H47N7O6S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(4-(((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)carbamoyl)piperazin-1-yl)ethyl 4-((diaminomethylene)amino)benzoate
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References
1. Haofeng Wang, et al. Nat Commun. 2023 Nov 21;14(1):7574.
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