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Compound 3-110-22

Chemical Structure : Compound 3-110-22

CAS No.: 2322313-72-2

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Compound 3-110-22

Catalog No.: PC-35283Not For Human Use, Lab Use Only.

Compound 3-110-22 is a small molecule that inhibits dengue virus (DENV) by binding to its envelope protein E.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Compound 3-110-22 is a small molecule that inhibits dengue virus (DENV) by binding to its envelope protein E.
    Compound 3-110-22 inhibits ZIKV PF13-251013-18 with IC90 of 4.0 uM, interacts with recombinant, soluble ZIKV E (ZIKV sE) in biolayer interferometry experiments with a KD of 2.1 uM。
    Compound 3-110-22 inhibits other flavivirus pathogens, inhibits DENV fusion by targeting E。
    Compound 3-110-22 also inhibits West Nile reporter virus with IC50 of 2.9 uM.

    Physicochemical Properties

    M.Wt 357.292
    Formula C18H10F3N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-2-(benzofuran-2-yl)-2-oxo-N-(3-(trifluoromethyl)phenyl)acetohydrazonoyl cyanide

    References

    1. de Wispelaere M, et al. Cell Chem Biol. 2018 Jun 1. pii: S2451-9456(18)30182-X.

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