Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Compound 401
CAS No.: 168425-64-7
Catalog No.: PC-45615Not For Human Use, Lab Use Only.
A synthetic inhibitor of DNA-PK also inhibits mTOR (IC50=5.3 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $28 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $228 | In stock | |
| 100 mg | $388 | In stock | |
| 250 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Compound 401 is a synthetic inhibitor of DNA-PK with IC50 of 0.28 uM, also inhibits mTOR (IC50=5.3 uM).
Compound 401 shows no inhibition on p110α/p85α PI3K (>100 uM).
Compound 401 blocks the phosphorylation of S6 kinase 1 Thr389 and Akt Ser473 in COS7 cells.
| M.Wt | 281.3092 | |
| Formula | C16H15N3O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: 6 mg/mL |
|
| Chemical Name/SMILES |
4H-Pyrimido[2,1-a]isoquinolin-4-one, 2-(4-morpholinyl)- |
|
1. Ballou LM, et al. J Biol Chem. 2007 Aug 17;282(33):24463-70.
2. Griffin RJ, et al. J Med Chem. 2005 Jan 27;48(2):569-85.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
