Chemical Structure : Compound 401
CAS No.: 168425-64-7
Catalog No.: PC-45615Not For Human Use, Lab Use Only.
Compound 401 is a synthetic inhibitor of DNA-PK with IC50 of 0.28 uM, also inhibits mTOR (IC50=5.3 uM).
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Compound 401 is a synthetic inhibitor of DNA-PK with IC50 of 0.28 uM, also inhibits mTOR (IC50=5.3 uM).
Compound 401 shows no inhibition on p110α/p85α PI3K (>100 uM).
Compound 401 blocks the phosphorylation of S6 kinase 1 Thr389 and Akt Ser473 in COS7 cells.
M.Wt | 281.3092 | |
Formula | C16H15N3O2 | |
Appearance | Solid | |
Storage |
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Solubility |
DMSO: 6 mg/mL |
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Chemical Name/SMILES |
4H-Pyrimido[2,1-a]isoquinolin-4-one, 2-(4-morpholinyl)- |
1. Ballou LM, et al. J Biol Chem. 2007 Aug 17;282(33):24463-70.
2. Griffin RJ, et al. J Med Chem. 2005 Jan 27;48(2):569-85.
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