Compound 621433144 |CAS:2223169-38-6 Probechem Biochemicals

Chemical Structure : Compound 621433144

Compound 621433144 (ZINC000621433144;Z3269026405)

Catalog No.: PC-36061Not For Human Use, Lab Use Only.

Compound 621433144 (ZINC000621433144, Z3269026405) is a potent, selective full agonist of the D4 receptor with 2,500-fold subtype selectivity.

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Biological Activity

Compound 621433144 (ZINC000621433144, Z3269026405) is a potent, selective full agonist of the D4 receptor with 2,500-fold subtype selectivity; Compound 621433144 was also functionally selective, with a 17-fold bias towards Gi signalling versus β-arrestin recruitment, compared to the characteristic agonist quinpirole.

Physicochemical Properties

M.Wt	301.434
Formula	C18H27N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-((3R,4S)-1-isopropyl-4-methylpyrrolidin-3-yl)-1-methylisoindoline-2-carboxamide

References

1. Lyu J, et al. Nature. 2019 Feb 6. doi: 10.1038/s41586-019-0917-9.

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Compound 621433144 (ZINC000621433144;Z3269026405)

Biological Activity

Physicochemical Properties

References

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