Compound 670551

Chemical Structure : Compound 670551

Catalog No.: PC-22323Not For Human Use, Lab Use Only.

Compound 670551 is a potent Cdc2-like kinase 2 (CLK2) inhibitor with IC50 of 619.7 nM, inhibits CLK activity by 96% at 10 uM.

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Biological Activity

Compound 670551 is a potent Cdc2-like kinase 2 (CLK2) inhibitor with IC50 of 619.7 nM, inhibits CLK2 activity by 96% at 10 uM.
Compound 670551 inhibits TNBC cell growth and survival.
Compound 670551 downregulates serine/arginine‐rich splicing factor (SRSF) phosphorylation and induces cell apoptosis.

Physicochemical Properties

M.Wt	288.35
Formula	C18H16N4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	9-(1-phenylethyl)-9H-pyrimido[4,5-b]indol-4-amine

References

1. Cheng-Chiao Huang, et al. Protein Sci. 2024 Jun;33(6):e5004.

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Compound 670551

Biological Activity

Physicochemical Properties

References

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