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Chemical Structure : Compound 7695-0983
Catalog No.: PC-22320Not For Human Use, Lab Use Only.
Compound 7695-0983 is a small molecule inhibitor of HLA-F locus-adjacent transcript 10 (FAT10), inhibits the expression of FAT10, inhibits NEDD4-PTEN/AKT axis-mediated autophagy.
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Compound 7695-0983 is a small molecule inhibitor of HLA-F locus-adjacent transcript 10 (FAT10), inhibits the expression of FAT10, inhibits NEDD4-PTEN/AKT axis-mediated autophagy.
Compound 7695-0983 binds to the active pocket of FAT10.
Compound 7695-0983 can enhance the sensitivity of HCC-SR cells to sorafenib.
Compound 7695-0983 combined with sorafenib could inhibit FAT10 to inhibit NEDD4-PTEN/AKT axis-mediated autophagy to increase sorafenib-induced apoptosis.
HLA-F locus-adjacent transcript 10 (FAT10) is a specific ubiquitin-like protein, which can directly mediate the ubiquitin-independent proteasomal degradation of substrates.
| M.Wt | 349.39 | |
| Formula | C20H19N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wenming Zhang, et al. Am J Cancer Res. 2024 Apr 15;14(4):1523-1544.
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