Chemical Structure : Compound 7695-0983
CAS No.:
727405-75-6
Compound 7695-0983
Catalog No.: PC-22320Not For Human Use, Lab Use Only.
Compound 7695-0983 is a small molecule inhibitor of HLA-F locus-adjacent transcript 10 (FAT10), inhibits the expression of FAT10, inhibits NEDD4-PTEN/AKT axis-mediated autophagy.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Compound 7695-0983 is a small molecule inhibitor of HLA-F locus-adjacent transcript 10 (FAT10), inhibits the expression of FAT10, inhibits NEDD4-PTEN/AKT axis-mediated autophagy.
Compound 7695-0983 binds to the active pocket of FAT10.
Compound 7695-0983 can enhance the sensitivity of HCC-SR cells to sorafenib.
Compound 7695-0983 combined with sorafenib could inhibit FAT10 to inhibit NEDD4-PTEN/AKT axis-mediated autophagy to increase sorafenib-induced apoptosis.
HLA-F locus-adjacent transcript 10 (FAT10) is a specific ubiquitin-like protein, which can directly mediate the ubiquitin-independent proteasomal degradation of substrates.
Physicochemical Properties
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M.Wt
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349.39
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Formula
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C20H19N3O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Ethyl 4-(3-hydroxyphenyl)-2-methyl-1,4-dihydropyrimido [1,2-a] benzimidazole-3-carboxylate
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References
1. Wenming Zhang, et al. Am J Cancer Res. 2024 Apr 15;14(4):1523-1544.
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