Compound MFH

Chemical Structure : Compound MFH

Catalog No.: PC-20549Not For Human Use, Lab Use Only.

Compound MFH is small molecule inhibitor of Wnt Signaling with IC50 of 25 uM in 293STF cells, binds to the CRD (cysteine-rich domain) domain of Wnt co-receptor Frizzled (Fzl).

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Biological Activity

Compound MFH is small molecule inhibitor of Wnt Signaling with IC50 of 25 uM in 293STF cells, binds to the CRD (cysteine-rich domain) domain of Wnt co-receptor Frizzled (Fzl). MFH binds to the CRD domain of Fzd and blocks both canonical and non-canonical Wnt signaling. effectively eliminate the ability of ex vivo LSC expansion and the ability of 3T3s to support ex vivo LSC expansion.

Physicochemical Properties

M.Wt	374.40
Formula	C22H18N2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(O)C1=CC=C(N/N=C2C3=C(C4=C\2C=C(OC)C=C4)C=CC(OC)=C3)C=C1

References

1. Zhang C, et al. iScience. 2020 May 22;23(5):101075.

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Compound MFH

Biological Activity

Physicochemical Properties

References

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