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Frizzled6 agonist SAG1.3

Frizzled6 agonist SAG1.3 is a small molecule SMO agonist that targets Frizzled6 (FZD6) as a partial agonist with limited subtype selectivity.


FzM1 is a negative allosteric modulator of the Frizzled4 (Fzd4) receptor and a Wnt/β-catenin pathway inhibitor with pEC50 value of 5.74 for inhibition of Wnt antagonism.


FzM1.8 is a small molecule, allosteric agonist of the Frizzled receptor Fzd4 with pEC50 of 6.4, potentiates β-catenin pathway in the absence of any WNT ligand.

SRI 37892

SRI 37892 (SRI37892) is a novel potent, small molecule Frizzled 7 (Fzd 7) inhibitor with IC50 of 0.66 uM in Wnt/β-catenin assay.

Compound MFH

Compound MFH is small molecule inhibitor of Wnt Signaling with IC50 of 25 uM in 293STF cells, binds to the CRD (cysteine-rich domain) domain of Wnt co-receptor Frizzled (Fzl).

Compound 3235-0367

Compounmd 3235-0367 is a small-molecule inhibitor of FZD8 with IC50 of 7.1 uM against mouse FZD8 cysteine-rich domain (CRD) by cell-based assays and KD of 2.5 uM inb BLI assays, inhibits Wnt3a-induced β-catenin signaling.

Peptide Fz7-21

Peptide Fz7-21 is a potent, selective peptide inhibitor of Frizzled 7 receptor, inhibits exogenous WNT3A stimulated Wnt-β-catenin signaling in HEK293 cells with IC50 of 100 nM.

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