NSC654259 |CAS:150068-95-4 Probechem Biochemicals

Chemical Structure : NSC654259

NSC654259 (NSC-654259;NSC 654259)

Catalog No.: PC-60868Not For Human Use, Lab Use Only.

NSC654259 is novel small molecule Wnt signaling inhibitor that targets the cysteine-rich domain of Frizzled, specifically binds to the Wnt binding site on the Frizzled 8 (FZD8) cysteine-rich domain with Kd of 2.9 uM, IC50 of 5.7 uM.

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Biological Activity

NSC654259 is novel small molecule Wnt signaling inhibitor that targets the cysteine-rich domain of Frizzled, specifically binds to the Wnt binding site on the Frizzled 8 (FZD8) cysteine-rich domain with Kd of 2.9 uM, IC50 of 5.7 uM.

Physicochemical Properties

M.Wt	535.783
Formula	C21H20BrClN6O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[(2-aminoacetyl)amino]-N-[[4-(5-bromopyrimidin-2-yl)oxy-3-methylphenyl]carbamoyl]benzamide;hydrochloride

References

1. Lee HJ, et al. J Biol Chem. 2015 Dec 18;290(51):30596-606.

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NSC654259 (NSC-654259;NSC 654259)

Biological Activity

Physicochemical Properties

References

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