Catalog No.: PC-60975Not For Human Use, Lab Use Only.
FzM1.8 is a small molecule, allosteric agonist of the Frizzled receptor Fzd4 with pEC50 of 6.4, potentiates β-catenin pathway in the absence of any WNT ligand.
FzM1.8 is a small molecule, allosteric agonist of the Frizzled receptor Fzd4 with pEC50 of 6.4, potentiates β-catenin pathway in the absence of any WNT ligand.
FzM1.8 biases FZD4 signaling toward a FZD4/PI3K axis that culminates into transactivation of β-catenin/TCF activity by the histone acetyltransferase CBP/p300.
FzM1.8 preserves stemness and promotes proliferation of undifferentiated cells.
