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Peptide Fz7-21

Chemical Structure : Peptide Fz7-21

CAS No.:

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Peptide Fz7-21

Catalog No.: PC-63300Not For Human Use, Lab Use Only.

Peptide Fz7-21 is a potent, selective peptide inhibitor of Frizzled 7 receptor, inhibits exogenous WNT3A stimulated Wnt-β-catenin signaling in HEK293 cells with IC50 of 100 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Peptide Fz7-21 is a potent, selective peptide inhibitor of Frizzled 7 receptor, inhibits exogenous WNT3A stimulated Wnt-β-catenin signaling in HEK293 cells with IC50 of 100 nM; also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells with IC50 of 50 nM; shows isoform-selective binding to the Fc-tagged FZD1, FZD2 and FZD7 CRDs with EC50 of 19-58 nM, whereas little to no binding to the FZD4, FZD5, FZD8, FZD9 or FZD10 CRDs; impaires Wnt signaling in cultured cells and stem cell function in intestinal organoids.

Physicochemical Properties

M.Wt
Formula
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Acetyl-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val-Met-Tyr-NH2

References

1. Nile AH, et al. Nat Chem Biol. 2018 Apr 9. doi: 10.1038/s41589-018-0035-2.

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