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SRI 37892

Chemical Structure : SRI 37892

CAS No.: 1030769-75-5

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SRI 37892 (SRI37892;SRI-37892)

Catalog No.: PC-60973Not For Human Use, Lab Use Only.

SRI 37892 (SRI37892) is a novel potent, small molecule Frizzled 7 (Fzd 7) inhibitor with IC50 of 0.66 uM in Wnt/β-catenin assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SRI 37892 (SRI37892) is a novel potent, small molecule Frizzled 7 (Fzd 7) inhibitor with IC50 of 0.66 uM in Wnt/β-catenin assay.
    SRI 37892 also displays potent activity against Wnt/β-catenin signaling in LRP6-expressing HEK293 cells with IC50 of 0.78 uM.
    SRI 37892 demonstrates potent activity against breast cancer HS578T and BT549 cell proliferation with IC50 of 2.2 and 1.9 uM, respectively.
    SRI 37892 targets Fzd7 transmembrane domain (TMD) and bolcks Wnt/Fzd7 signaling.

    Physicochemical Properties

    M.Wt 465.531
    Formula C26H19N5O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(1H-benzo[d]imidazol-1-yl)-N-(4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiazol-2-yl)benzamide

    References

    1. Zhang W, et al. Oncotarget. 2017 Sep 6;8(53):91459-91470.

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