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Chemical Structure : FZD7 antagonist F7H
Catalog No.: PC-21133Not For Human Use, Lab Use Only.
FZD7 antagonist F7H is a small molecule antagonist of the transmembrane domain of frizzled receptor FZD7 (FZD7-TMD, SPR KD=0.16 uM), blocks Wnt3A-mediated stabilization of β-catenin in HEK293T cells with IC50 of 1.25 uM.
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FZD7 antagonist F7H is a small molecule antagonist of the transmembrane domain of frizzled receptor FZD7 (FZD7-TMD, SPR KD=0.16 uM), blocks Wnt3A-mediated stabilization of β-catenin in HEK293T cells with IC50 of 1.25 uM.
FZD7 antagonist F7H does not bind the SMO protein indicative of the potential selectivity.
| M.Wt | 463.55 | |
| Formula | C24H18FN3O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Li C, et al. J Med Chem. 2023 Sep 5. doi: 10.1021/acs.jmedchem.2c01795.
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