FZD7 antagonist F7H

Chemical Structure : FZD7 antagonist F7H

Catalog No.: PC-21133Not For Human Use, Lab Use Only.

FZD7 antagonist F7H is a small molecule antagonist of the transmembrane domain of frizzled receptor FZD7 (FZD7-TMD, SPR KD=0.16 uM), blocks Wnt3A-mediated stabilization of β-catenin in HEK293T cells with IC50 of 1.25 uM.

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Biological Activity

Physicochemical Properties

M.Wt	463.55
Formula	C24H18FN3O2S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Fluoro-N-(4-((2-oxo-2-((4-phenylthiazol-2-yl)amino)ethyl)thio)phenyl)benzamide

References

1. Li C, et al. J Med Chem. 2023 Sep 5. doi: 10.1021/acs.jmedchem.2c01795.

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FZD7 antagonist F7H

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

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