Conduritol B epoxide is a potent, specific, irreversible glucocerebrosidase (β-glucosidase) inhibitor with Ki of 53 uM.
Conduritol B epoxide does not inhibit non-lysosomal glucosylceramidase or cytosolic β-glucosidase.
Conduritol B epoxide is a useful tool to study Gaucher disease.
Physicochemical Properties
M.Wt
162.1406
Formula
C6H10O5
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
H2O: ≥ 22 mg/mL
Chemical Name/SMILES
myo-Inositol, 1,2-anhydro-
References
1. Ogawa S, et al. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1493-8.
2. Witte MD, et al. Nat Chem Biol. 2010 Dec;6(12):907-13.
3. Newburg DS, et al. Biochim Biophys Acta. 1986 Jun 11;877(1):121-6.
4. Liou B, et al. Hum Mol Genet. 2016 Dec 1;25(23):5126-5141.
