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Conduritol B epoxide

Chemical Structure : Conduritol B epoxide

CAS No.: 6090-95-5

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Conduritol B epoxide (CBE)

Catalog No.: PC-42291Not For Human Use, Lab Use Only.

A potent, specific, irreversible glucocerebrosidase (acid β-glucosidase) inhibitor with Ki of 53 uM.

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25 mg $128 In stock
50 mg $216 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A potent, specific, irreversible glucocerebrosidase (acid β-glucosidase) inhibitor with Ki of 53 uM; does not inhibit non-lysosomal glucosylceramidase or cytosolic β-glucosidase; a useful tool to study Gaucher disease.

Physicochemical Properties

M.Wt 162.1406
Formula C6H10O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

H2O: ≥ 22 mg/mL
Chemical Name/SMILES

myo-Inositol, 1,2-anhydro-

References

1. Ogawa S, et al. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1493-8.

2. Witte MD, et al. Nat Chem Biol. 2010 Dec;6(12):907-13.

3. Newburg DS, et al. Biochim Biophys Acta. 1986 Jun 11;877(1):121-6.

4. Liou B, et al. Hum Mol Genet. 2016 Dec 1;25(23):5126-5141.

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