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Chemical Structure : Coronastat
CAS No.: 2922281-15-8
Catalog No.: PC-73341Not For Human Use, Lab Use Only.
Coranastat (NK01-63) is a GC376 analog with improved potency, and highly potent, selective SARS-CoV-2 3CL protease inhibitor with IC50 of 16 nM, exhibits antiviral potency with EC50 of 6 nM in Huh-7ACE2 cellular assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 25 mg | $558 | In stock | |
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Coranastat (NK01-63) is a GC376 analog with improved potency, and highly potent, selective SARS-CoV-2 3CL protease inhibitor with IC50 of 16 nM, exhibits antiviral potency with EC50 of 6 nM in Huh-7ACE2 cellular assays.
NK01-63 exhibited outstanding improvements over GC376 for inhibiting SARS-CoV-2 in vitro and in cells, demonstrated high potency in human Caco-2 cells against SARS-CoV-2 infection with EC90 of 81 nM.
NK01-63 is highly selective for 3CL inhibition, displaying IC50 values of >100 μM against many of the other human proteases and possessing only modest levels of inhibition of caspase 8 (IC50=18 µM), cathepsin B (IC50=1.1 µM), cathepsin K (IC50=0.04 µM), and cathepsin S (IC50=0.03 uM), but with high potency against cathepsin L (IC50=0.006 uM).
NK01-63 exhibits specific pan-coronavirus activities, can effectively block the viral replication of human coronavirus alpha OC43 and human coronavirus beta 229E, with EC50 values < 100 nM in Huh-7 human cells, also blocks replication of MERS-CoV (EC50< 1 µM) and SARS-CoV (EC50< 3 µM) in Vero 76 cells.
| M.Wt | 575.532 | |
| Formula | C22H29F3N3NaO8S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
sodium (2S)-1-hydroxy-2-((S)-4-methyl-2-((((3-(trifluoromethyl)benzyl)oxy)carbonyl)amino)pentanamido)-3-((S)-2-oxopyrrolidin-3-yl)propane-1-sulfonate |
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1. Hengrui Liu, et al. Nat Commun. 2022 Apr 7;13(1):1891.
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