Catalog No.: PC-45987Not For Human Use, Lab Use Only.
Cortodoxone (11-Deoxycortisol, Cortexolone) is a glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone), exhibits corticosteroid binding characteristics, including DNA binding.
Cortodoxone (11-Deoxycortisol, Cortexolone) is a glucocorticoid steroid hormone that can be oxygenated to cortisol (Hydrocortisone), exhibits corticosteroid binding characteristics, including DNA binding.
11-deoxycortisol is regulated by the hypothalamus-pituitary axis and responded to acute stress.
Cortodoxone impedes GABAergic neurotransmission and induces drug-resistant status epilepticus in mice.
Physicochemical Properties
M.Wt
346.4605
Formula
C21H30O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 33 mg/mL
Chemical Name/SMILES
Pregn-4-ene-3,20-dione, 17,21-dihydroxy-
References
1. Close DA, et al. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13942-7.
2. Kaminski RM, et al. Neuropharmacology. 2011 Jun;60(7-8):1098-108.
3. Baker ME, et al. Steroids. 2011 Dec 11;76(13):1451-7.
