Cotransin CT8 | Sec61 modulator | Probechem Biochemicals

Chemical Structure : Cotransin CT8

Cotransin CT8 (CT-08, Co-translational translocation inhibitor)

Catalog No.: PC-21747Not For Human Use, Lab Use Only.

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Biological Activity

Cotransin CT8 (CT-08) is a substrate-selective co-translational translocation inhibitor, binds the Sec61 translocon to inhibit cotranslational translocation of a subset of secreted and type I transmembrane proteins.
Cotransin CT8 (CT-08) inhibits DENV replication in primary human monocyte-derived dendritic cells.
Cotransin CT8 (CT-08) inhibit secretory and transmembrane protein expression.
Cotransin CT8 (CT-08) inhibits cotranslational translocation of TNFα, a type II transmembrane protein that lacks a cleavable signal sequence.
Cotransin CT8 (CT-08) exhibits selectivity for VCAM and TNFα, affecting most of the remaining proteins only at higher concentrations.

Physicochemical Properties

M.Wt	893.22
Formula	C50H80N6O8
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,6S,9S,12S,15S,18S,21R)-9-benzyl-12,15-diisobutyl-3,4,10,16-tetramethyl-6,18-bis((R)-2-methylhexyl)-21-(prop-2-yn-1-yl)-1-oxa-4,7,10,13,16,19-hexaazacyclohenicosane-2,5,8,11,14,17,20-heptaone

References

1. Sarah V Maifeld, et al. Chem Biol. 2011 Sep 23;18(9):1082-8.

2. Priya S Shah, et al. Cell. 2018 Dec 13;175(7):1931-1945.e18.

Cotransin CT8 (CT-08, Co-translational translocation inhibitor)

Biological Activity

Physicochemical Properties

References

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