Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Cotransin CT8
Catalog No.: PC-21747Not For Human Use, Lab Use Only.
Cotransin CT8 (CT-08) is a substrate-selective co-translational translocation inhibitor, binds the Sec61 translocon to inhibit cotranslational translocation of a subset of secreted and type I transmembrane proteins.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Cotransin CT8 (CT-08) is a substrate-selective co-translational translocation inhibitor, binds the Sec61 translocon to inhibit cotranslational translocation of a subset of secreted and type I transmembrane proteins.
Cotransin CT8 (CT-08) inhibits DENV replication in primary human monocyte-derived dendritic cells.
Cotransin CT8 (CT-08) inhibit secretory and transmembrane protein expression.
Cotransin CT8 (CT-08) inhibits cotranslational translocation of TNFα, a type II transmembrane protein that lacks a cleavable signal sequence.
Cotransin CT8 (CT-08) exhibits selectivity for VCAM and TNFα, affecting most of the remaining proteins only at higher concentrations.
| M.Wt | 893.22 | |
| Formula | C50H80N6O8 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Sarah V Maifeld, et al. Chem Biol. 2011 Sep 23;18(9):1082-8.
2. Priya S Shah, et al. Cell. 2018 Dec 13;175(7):1931-1945.e18.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
