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Cotransin CT9

Chemical Structure : Cotransin CT9

CAS No.: 438239-90-8

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Cotransin CT9 (CT-09, Co-translational translocation inhibitor)

Catalog No.: PC-21748Not For Human Use, Lab Use Only.

Cotransin CT9 (CT-09) is a substrate-selective co-translational translocation inhibitor, binds the Sec61 translocon to inhibit cotranslational translocation of a subset of secreted and type I transmembrane proteins.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Cotransin CT9 (CT-09) is a substrate-selective co-translational translocation inhibitor, binds the Sec61 translocon to inhibit cotranslational translocation of a subset of secreted and type I transmembrane proteins.

Physicochemical Properties

M.Wt 1037.40
Formula C59H88N8O8
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-((2R,17S,20S)-14-((1-benzyl-1H-indol-3-yl)methyl)-8,11-diisobutyl-7,13,19,20-tetramethyl-5,17-bis((R)-2-methylhexyl)-3,6,9,12,15,18,21-heptaoxo-1-oxa-4,7,10,13,16,19-hexaazacyclohenicosan-2-yl)propanenitrile

References

1. Priya S Shah, et al. Cell. 2018 Dec 13;175(7):1931-1945.e18.

2. Sarah V Maifeld, et al. Chem Biol. 2011 Sep 23;18(9):1082-8.

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