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Cyanorona-20

Chemical Structure : Cyanorona-20

CAS No.: 2866211-96-1

Cyanorona-20 (Cyanorona 20)

Catalog No.: PC-72126Not For Human Use, Lab Use Only.

Cyanorona-20 is a potent and specific SARS-CoV-2 inhibitor with very high selectivity (209- and 45-fold more potent than favipiravir and remdesivir, respectively), effectively binds to and inhibits the SARS-CoV-2 RdRp.

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    Biological Activity

    Cyanorona-20 is a potent and specific SARS-CoV-2 inhibitor with very high selectivity (209- and 45-fold more potent than favipiravir and remdesivir, respectively), effectively binds to and inhibits the SARS-CoV-2 RdRp.
    Cyanorona-20 exhibited very significant anti-COVID-19 activity (anti-SARS-CoV-2 viral redcution EC50=0.45 uM, CPE IC100=1.4 uM, 50% reduction in viral RNA EC50=0.48 uM), SARS-CoV-2 in vitro.
    Cyanorona-20 strongly binds with the pivotal amino acid residue of the SARS-CoV-2 RdRp active site, Asp760.

    Physicochemical Properties

    M.Wt 270.223
    Formula C13H7FN4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    [N(E)]-N-[(4-Cyanophenyl)methylene]-6-fluoro-3,4-dihydro-3-oxo-2-pyrazinecarboxamide

    References

    1. Rabie AM. Chem Zvesti. 2021 May 16:1-17.

    2. Rabie AM. Int Immunopharmacol. 2021 Sep;98:107831.

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