Chemical Structure : Cyanotriazole CT3
CAS No.:
2403729-27-9
Cyanotriazole CT3
Catalog No.: PC-20947Not For Human Use, Lab Use Only.
Cyanotriazole CT3 is a potent, selective, irreversible inhibitor of trypanosomal topoisomerase II, shows potent trypanocidal activity both in vitro and in vivo.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Cyanotriazole CT3 is a potent, selective, irreversible inhibitor of trypanosomal topoisomerase II, shows potent trypanocidal activity both in vitro and in vivo.
Cyanotriazole CT3 is a potent growth inhibitor of a panel of kinetoplastid parasites, which includes T. cruzi and L. donovani (EC50, 78 and 134 nM), but has no activity against a range of nontrypanosomatid microbial pathogens.
Cyanotriazole CT3 (30 mg/kg) is efficacious against trypanosomatid parasites in vivo.
Cyanotriazole CT3-treated parasites showes defects in nuclear DNA replication, exhibited up-regulated DNA damage response.
Cyanotriazole CT3 selectively inhibits the DNA relaxation activity of trypanosome TopoII by stabilizing the dsDNA:enzyme complex, interacts covalently with C477 and bind at the DNA cleavage site.
Physicochemical Properties
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M.Wt
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416.34
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Formula
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C19H12F4N6O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N#CC1=NN(CC(N2CC3=C(C=C(C4=CC(F)=CN=C4C(F)(F)F)C=C3)C2)=O)C=N1
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References
1. Srinivasa P S Rao, et al. Science. 2023 Jun 30;380(6652):1349-1356.
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