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Cyclin K degrader DS17

Chemical Structure : Cyclin K degrader DS17

CAS No.:

Cyclin K degrader DS17

Catalog No.: PC-21140Not For Human Use, Lab Use Only.

Cyclin K degrader DS17 is a selective cyclin K molecular glue degrader with TR-FRET EC50 of 19 nM.

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Purity & Documentation Purity: 99.64% (HPLC) Select Batch:

Biological Activity

Cyclin K degrader DS17 is a selective cyclin K molecular glue degrader with TR-FRET EC50 of 13 nM.
Cyclin K degrader DS17 is more effective at depleting cyclin K than CR8 at 1 µM concentration.
Cyclin K degrader DS17 acquires glue activity via simultaneous CDK12 binding and engagement of DDB1 interfacial residues, in particular Arg928.

Physicochemical Properties

M.Wt 463.37
Formula C20H24Cl2N8O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-2-((6-(((5,6-dichloro-1H-benzo[d]imidazol-2-yl)methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol

References

1. Zuzanna Kozicka, et al. Nat Chem Biol. 2023 Sep 7. doi: 10.1038/s41589-023-01409-z.

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