Cyclin K degrader DS17

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Chemical Structure : Cyclin K degrader DS17

CAS No.:

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Catalog No.: PC-21140Not For Human Use, Lab Use Only.

Cyclin K degrader DS17 is a selective cyclin K molecular glue degrader with TR-FRET EC50 of 19 nM.

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5 mg	$328	In stock
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Purity & Documentation Purity: 99.64% (HPLC) Select Batch:

Biological Activity

Cyclin K degrader DS17 is a selective cyclin K molecular glue degrader with TR-FRET EC50 of 13 nM.
Cyclin K degrader DS17 is more effective at depleting cyclin K than CR8 at 1 µM concentration.
Cyclin K degrader DS17 acquires glue activity via simultaneous CDK12 binding and engagement of DDB1 interfacial residues, in particular Arg928.

Physicochemical Properties

M.Wt	463.37
Formula	C20H24Cl2N8O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-((6-(((5,6-dichloro-1H-benzo[d]imidazol-2-yl)methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol

References

1. Zuzanna Kozicka, et al. Nat Chem Biol. 2023 Sep 7. doi: 10.1038/s41589-023-01409-z.

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