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Chemical Structure : Cysmethynil
CAS No.: 851636-83-4
Catalog No.: PC-70250Not For Human Use, Lab Use Only.
Cysmethynil is a selective small-molecule inhibitor of tisoprenylcysteine carboxyl methyltransferase (Icmt) with IC50 <200 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $358 | In stock | |
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| 100 mg | Get quote |
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Cysmethynil is a selective small-molecule inhibitor of tisoprenylcysteine carboxyl methyltransferase (Icmt) with IC50 <200 nM.
Cysmethynil does not inhibit other enzymes (farensyltransferase, geranylgeranyltransferase type I, and Rce1) at concentrations up to 50 uM.
Cysmethynil acts as a competitive inhibitor with respect to the isoprenylated cysteine substrate and a noncompetitive inhibitor with respect to S-adenosylmethionine (Ki=0.14 uM).
Cysmethynil causes decrease in Ras carboxylmethylation, mislocalization of Ras, and impaired signaling through Ras pathways, reduces mTOR signaling and results in both an accumulation of cells in the G(1) phase and cell death in PC3 cells.
| M.Wt | 376.5 | |
| Formula | C25H32N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(3-Methylphenyl)-1-octyl-1H-indole-3-acetamide |
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1. Winter-Vann AM, et al. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4336-41.
2. Baron RA, et al. Biochemistry. 2007 Jan 16;46(2):554-60.
3. Wang M, et al. J Biol Chem. 2008 Jul 4;283(27):18678-84.
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