D-4-77

Chemical Structure : D-4-77

Catalog No.: PC-21119Not For Human Use, Lab Use Only.

D-4-77 is a potent, covalent peptidyl inhibitor of SARS-CoV-2 main protease (Mpro) with IC50 of 0.95 uM and antiviral EC50 of 0.49 uM.

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Biological Activity

D-4-77 is a potent, covalent peptidyl inhibitor of SARS-CoV-2 main protease (Mpro) with IC50 of 0.95 uM and antiviral EC50 of 0.49 uM.
D-4-77 binds to the S1'-S3' pocket and revealed a covalent mechanism.
D-4-77 functions as an immune protectant and suppresses SARS-CoV-2 Mpro-induced antagonism of the host NF-κB innate immune response.

Physicochemical Properties

M.Wt	512.45
Formula	C23H34BrN3O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (S)-2-((2S,3S)-2-((S)-2-(2-bromoacetamido)propanamido)-3-methylpentanamido)-3-(2,4-dimethylphenyl)propanoate

References

1. Ming Liu, et al. Angew Chem Int Ed Engl. 2023 Aug 23;e202309657.

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D-4-77

Biological Activity

Physicochemical Properties

References

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