D-F07

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Chemical Structure : D-F07

Catalog No.: PC-47077Not For Human Use, Lab Use Only.

D-F07 is a novel fluorescent, covalent IRE-1 inhibitor, potently inhibits XBP-1s expression in MM cells.

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Biological Activity

D-F07 is a novel fluorescent, covalent IRE-1 inhibitor, potently inhibits XBP-1s expression in MM cells.
D-F07 suppressed the expression of XBP-1s in both human and mouse myeloma cells in a dose-dependent manner.

Physicochemical Properties

M.Wt	347.367
Formula	C18H21NO6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(1,3-dioxan-2-yl)-8-hydroxy-9-methoxy-3-methyl-1,2,3,4-tetrahydro-5H-chromeno[3,4-c]pyridin-5-one

References

1. Andong Shao, et al. J Med Chem. 2019 Jun 13;62(11):5404-5413.

2. Andong Shao, et al. Mol Cancer Ther. 2020 Dec;19(12):2432-2444.

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D-F07

Biological Activity

Physicochemical Properties

References

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