Chemical Structure : D-e-MAPP
CAS No.:
143492-38-0
D-e-MAPP
(D-erythro-MAPP)
Catalog No.: PC-28566Not For Human Use, Lab Use Only.
D-e-MAPP (D-erythro-MAPP) is a ceramide analogue and specific inhibitor of alkaline ceramidase, inhibits alkaline ceramidase activity in vitro with IC50 of 1-5 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
D-e-MAPP (D-erythro-MAPP) is a ceramide analogue and specific inhibitor of alkaline ceramidase, inhibits alkaline ceramidase activity in vitro with IC50 of 1-5 uM.
D-e-MAPP does not modulate the activity of other ceramide metabolizing enzymes in vitro or in cells, and is a poor inhibitor of acid ceramidase (IC50>500 microM).
D-e-MAPP treatment elevates endogenous levels of ceramide with the consequent biologic effects of growth suppression and cell cycle arrest in HL-60 human promyelocytic leukemia cells.
D-e-MAPP induces apoptosis and suppression of proliferation in HaCaT keratinocytes.
Physicochemical Properties
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M.Wt
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361.57
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Formula
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C23H39NO2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-[(1R,2S)-2-Hydroxy-1-methyl-2-phenylethyl]-tetradecanamide
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References
1. Bielawska A, et al. J Biol Chem. 1996 May 24;271(21):12646-54.
2. Raisova M, et al. FEBS Lett. 2002 Apr 10;516(1-3):47-52.
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