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Chemical Structure : D156844
Catalog No.: PC-70082Not For Human Use, Lab Use Only.
D156844 (D 156844) is a potent, orally bioavailable SMN2 promoter activator with EC50 of 4 nM and 2.3-fold induction of the SMN2 promoter, a potent inhibitor of the mRNA decapping enzyme DcpS.
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D156844 (D 156844) is a potent, orally bioavailable SMN2 promoter activator with EC50 of 4 nM and 2.3-fold induction of the SMN2 promoter, a potent inhibitor of the mRNA decapping enzyme DcpS.
D156844 up-regulates expression of the mouse SMN gene in NSC-34 cells, induces SMN in a dose-dependent manner in type 1 SMA patient fibroblasts.
D156844 possesses desirable pharmaceutical properties, including excellent brain exposure and long brain half-life.
| M.Wt | 381.455 | |
| Formula | C21H24FN5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Butchbach ME, et al. Hum Mol Genet. 2010 Feb 1;19(3):454-67.
2. Butchbach ME, et al. Exp Neurol. 2014 Jun;256:1-6.
3. Thurmond J, et al. J Med Chem. 2008 Feb 14;51(3):449-69.
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