Catalog No.: PC-70082Not For Human Use, Lab Use Only.
D156844 (D 156844) is a potent, orally bioavailable SMN2 promoter activator with EC50 of 4 nM and 2.3-fold induction of the SMN2 promoter, a potent inhibitor of the mRNA decapping enzyme DcpS.
D156844 (D 156844) is a potent, orally bioavailable SMN2 promoter activator with EC50 of 4 nM and 2.3-fold induction of the SMN2 promoter, a potent inhibitor of the mRNA decapping enzyme DcpS. D156844 up-regulates expression of the mouse SMN gene in NSC-34 cells, induces SMN in a dose-dependent manner in type 1 SMA patient fibroblasts. D156844 possesses desirable pharmaceutical properties, including excellent brain exposure and long brain half-life.
