| Cat. No. |
Product Name |
Information |
| PC-49646 |
SMN antagonist 1
SMN inhibitor
|
SMN antagonist 1 (Compound 1) is a small molecule antagonist of Survival of motor neuron (SMN), preferentially binds to SMN (Kd=2.6 uM) among assayed methylarginine or methyllysine binders, disrupts the SMN-RNAP II interaction. |
| PC-35177 |
PK4C9
|
PK4C9 (Homocarbonyltopsentin) is a small-molecule stem-loop RNA structure TSL2-binding compound (EC50=16.1 uM) that increases SMN2 exon 7 (E7) splicing and rescues downstream molecular alterations in SMA cells. |
| PC-62370 |
Cuspin-1
SMN2 splicing modulator
|
Cuspin-1 is a small molecule upregulator of SMN (Survival of Motor Neuron protein) with EC50 of 18 uM. |
| PC-61397 |
Risdiplam
SMN2 splicing modulator
|
Risdiplam (RG7916, RG-7916, RO7034067) is a highly potent, selective, orally active SMN2 splicing modifier for treatment of spinal muscular atrophy (SMA). |
| PC-70082 |
D-156844
|
D-156844 (D156844) is a potent, orally bioavailable SMN2 promoter activator with EC50 of 4 nM and 2.3-fold induction of the SMN2 promoter, a potent inhibitor of the mRNA decapping enzyme DcpS. |
| PC-45659 |
LMI-070
SMN2 splicing modulator
|
LMI070 (NVS-SM1, Branaplam) is a potent SMN2 splice modulator (EC50=20 nM) that potential treatment of spinal muscular atrophy (SMA). |
| PC-42423 |
RG7800
SMN2 splicing modulator
|
RG7800 (RG-7800, RO6885247) is a potent, orally available, small molecule SMN2 splicing modifier with EC1.5X of 23 nM and 87 nM for SMN2 splicing and SMN2 protein, respectively. |
| PC-72088 |
SMN2 splicing modulator TEC-1
SMN2 splicing modulator
|
SMN2 splicing modulator TEC-1 is a novel specific, CNS penetrant small molecule SMN2 splicing modulator, increases the expression level of FL-SMN2 mRNA and decreases the expression level of Δ7 mRNA. |
| PC-63445 |
SMN-C3
|
SMN-C2 is a close analogs of RG-7916 act as selective RNA-binding ligands that modulate pre-mRNA splicing. |
| PC-63444 |
SMN-C2
|
SMN-C2 is a close analogs of RG-7916 act as selective RNA-binding ligands that modulate pre-mRNA splicing. |
| PC-62675 |
SMN-C3
|
SMN-C3 is a selective, orally available small molecule SMN2 splicing modifier toward the production of full-length SMN2 messenger RNA with high selectivity. |
| PC-62139 |
ML372
|
ML372 is a small molecule SMN modulator that increases SMN protein in patient fibroblasts with EC50 of 37 nM. |
