LDN-75654 | SMN2 modulator | Probechem Biochemicals

Chemical Structure : LDN-75654

Catalog No.: PC-61636Not For Human Use, Lab Use Only.

LDN-75654 is a novel potent SMN2 modulator (EC50=1.8 uM, Emax 186%), increases SMN protein in spinal cord and brain in mice.

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Biological Activity

LDN-75654 is a novel potent SMN2 modulator (EC50=1.8 uM, Emax 186%), increases SMN protein in spinal cord and brain in mice.

M.Wt	282.699
Formula	C13H12ClFN2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-Chloro-4-fluorophenyl)-5-(1-methylethyl)-3-isoxazolecarboxamide

1. Rietz A, et al. J Med Chem. 2017 Jun 8;60(11):4594-4610.