Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-Others-SMN2 Modulator-SMN2 modulator 27
SMN2 modulator 27

Chemical Structure : SMN2 modulator 27

CAS No.: 1537150-15-4

SMN2 modulator 27

Catalog No.: PC-61634Not For Human Use, Lab Use Only.

SMN2 modulator 27 is a novel SMN2 modulator that stabilize the SMN protein with EC50 of 0.29 uM.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SMN2 modulator 27 is a novel SMN2 modulator that stabilize the SMN protein with EC50 of 0.29 uM.
    SMN2 modulator 27 shows excellent in vitro properties and a promising mouse PK profile, stabilizes the SMN protein, unrelated to global proteasome or autophagy inhibition.
    SMN2 modulator 27 shows a novel therapeutic mechanism that should complement other modalities for treatment of SMA.

    Physicochemical Properties

    M.Wt 326.77
    Formula C14H12ClFN2O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3-Chloro-4-fluoro-N-(5-(1-hydroxycyclobutyl)thiazol-2-yl)benzamide

    References

    1. Rietz A, et al. J Med Chem. 2017 Jun 8;60(11):4594-4610.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: