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Chemical Structure : SMN2 modulator 27
Catalog No.: PC-61634Not For Human Use, Lab Use Only.
SMN2 modulator 27 is a novel SMN2 modulator that stabilize the SMN protein with EC50 of 0.29 uM.
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SMN2 modulator 27 is a novel SMN2 modulator that stabilize the SMN protein with EC50 of 0.29 uM.
SMN2 modulator 27 shows excellent in vitro properties and a promising mouse PK profile, stabilizes the SMN protein, unrelated to global proteasome or autophagy inhibition.
SMN2 modulator 27 shows a novel therapeutic mechanism that should complement other modalities for treatment of SMA.
| M.Wt | 326.77 | |
| Formula | C14H12ClFN2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rietz A, et al. J Med Chem. 2017 Jun 8;60(11):4594-4610.
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