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Chemical Structure : SMN-C3-1
Catalog No.: PC-63445Not For Human Use, Lab Use Only.
SMN-C3 is a close analogs of RG7916 act as selective RNA-binding ligands that modulate pre-mRNA splicing, modulates SMN2 alternative splicing and increases SMN protein levels.
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SMN-C3-1 is a close analogs of RG7916 act as selective RNA-binding ligands that modulate pre-mRNA splicing, modulates SMN2 alternative splicing and increases SMN protein levels.
SMN-C3 directly binds to the AGGAAG motif on exon 7 of the SMN2 pre-mRNA, and promotes a conformational change in two to three unpaired nucleotides at the junction of intron 6 and exon 7 in both in vitro and in-cell models.
SMN-C3 increases binding of the splicing modulators, far upstream element binding protein 1 (FUBP1) and its homolog, KH-type splicing regulatory protein (KHSRP), to the SMN-C2/C3-SMN2 pre-mRNA complex and enhances SMN2 splicing.
| M.Wt | 417.517 | |
| Formula | C23H27N7O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang J, et al. Proc Natl Acad Sci U S A. 2018 Apr 30. pii: 201800260.
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