LDN-76070 | SMN2 modulator | Probechem Biochemicals

Chemical Structure : LDN-76070

Catalog No.: PC-61635Not For Human Use, Lab Use Only.

LDN-76070 is a novel potent SMN2 modulator (EC50=8.3 uM, Emax 186%), increases SMN protein in spinal cord and brain in mice (5 mg/kg).

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Biological Activity

LDN-76070 is a novel potent SMN2 modulator (EC50=8.3 uM, Emax 186%), increases SMN protein in spinal cord and brain in mice (5 mg/kg).

M.Wt	410.239
Formula	C18H17BrFNO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(5-bromo-2-fluorophenyl)-5,6,7-trimethoxy-3,4-dihydroquinolin-2(1H)-one

1. Rietz A, et al. J Med Chem. 2017 Jun 8;60(11):4594-4610.

2. Cherry JJ, et al. EMBO Mol Med. 2013 Jul;5(7):1103-18.