SMN-C3 | SMN2 splicing modulator | Probechem Biochemicals

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Chemical Structure : SMN-C3

CAS No.: 1449597-34-5

SMN-C3 (SMN2 splicing modulator)

Catalog No.: PC-62675Not For Human Use, Lab Use Only.

SMN-C3 is a selective, orally available small molecule SMN2 splicing modifier toward the production of full-length SMN2 messenger RNA with high selectivity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SMN-C3 is a selective, orally available small molecule SMN2 splicing modifier toward the production of full-length SMN2 messenger RNA with high selectivity.
SMN-C3 increases SMN protein levels, improves motor function, and protects of the neuromuscular circuit in Δ7 mice.
SMN-C3 also extends the life span of the mice.

Physicochemical Properties

M.Wt	416.529
Formula	C24H28N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4H-Pyrido[1,2-a]pyrimidin-4-one, 2-(4,6-dimethylpyrazolo[1,5-a]pyrazin-2-yl)-7-(1-ethyl-4-piperidinyl)-9-methyl-

References

1. Naryshkin NA, et al. Science. 2014 Aug 8;345(6197):688-93.

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SMN-C3 (SMN2 splicing modulator)

Biological Activity

Physicochemical Properties

References

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