| Cat. No. |
Product Name |
Information |
| PC-61397 |
Risdiplam
SMN2 splicing modulator
|
Risdiplam (RG7916, RG-7916, RO7034067) is a highly potent, selective, orally active SMN2 splicing modifier for treatment of spinal muscular atrophy (SMA). |
| PC-70082 |
D156844
SMN2 activator
|
D156844 (D 156844) is a potent, orally bioavailable SMN2 promoter activator with EC50 of 4 nM and 2.3-fold induction of the SMN2 promoter, a potent inhibitor of the mRNA decapping enzyme DcpS. |
| PC-45659 |
LMI070
SMN2 splicing modulator
|
LMI070 (NVS-SM1, Branaplam) is a potent SMN2 splice modulator (EC50=20 nM), shows potential treatment of spinal muscular atrophy (SMA). |
| PC-42423 |
RG7800
SMN2 splicing modulator
|
RG7800 (RG-7800, RO6885247) is a potent, orally available, small molecule SMN2 splicing modifier with EC1.5X of 23 nM and 87 nM for SMN2 splicing and SMN2 protein, respectively. |
