SMN2 Modulator (inhibitors, antagonists, agonists)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-61397	Risdiplam SMN2 splicing modulator	Risdiplam (RG7916, RG-7916, RO7034067) is a highly potent, selective, orally active SMN2 splicing modifier for treatment of spinal muscular atrophy (SMA).
PC-70082	D156844 SMN2 activator	D156844 (D 156844) is a potent, orally bioavailable SMN2 promoter activator with EC50 of 4 nM and 2.3-fold induction of the SMN2 promoter, a potent inhibitor of the mRNA decapping enzyme DcpS.
PC-45659	LMI070 SMN2 splicing modulator	LMI070 (NVS-SM1, Branaplam) is a potent SMN2 splice modulator (EC50=20 nM), shows potential treatment of spinal muscular atrophy (SMA).
PC-42423	RG7800 SMN2 splicing modulator	RG7800 (RG-7800, RO6885247) is a potent, orally available, small molecule SMN2 splicing modifier with EC1.5X of 23 nM and 87 nM for SMN2 splicing and SMN2 protein, respectively.

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