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Chemical Structure : LMI070
CAS No.: 1562338-42-4
Catalog No.: PC-45659Not For Human Use, Lab Use Only.
LMI070 (NVS-SM1, Branaplam) is a potent SMN2 splice modulator (EC50=20 nM), shows potential treatment of spinal muscular atrophy (SMA).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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LMI070 (NVS-SM1, Branaplam) is a potent SMN2 splice modulator (EC50=20 nM), shows potential treatment of spinal muscular atrophy (SMA).
| M.Wt | 393.4821 | |
| Formula | C22H27N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 6.12 mg/mL |
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| Chemical Name/SMILES |
Phenol, 5-(1H-pyrazol-4-yl)-2-[6-[(2,2,6,6-tetramethyl-4-piperidinyl)oxy]-3-pyridazinyl]- |
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1. Calder AN, et al. J Med Chem. 2016 Nov 23;59(22):10067-10083.
2. Palacino J, et al. Nat Chem Biol. 2015 Jul;11(7):511-7.
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