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PK4C9

Chemical Structure : PK4C9

CAS No.: 172286-77-0

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PK4C9 (Homocarbonyltopsentin)

Catalog No.: PC-35177Not For Human Use, Lab Use Only.

PK4C9 (Homocarbonyltopsentin) is a small-molecule stem-loop RNA structure TSL2-binding compound (EC50=16.1 uM) that increases SMN2 exon 7 (E7) splicing and rescues downstream molecular alterations in SMA cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PK4C9 (Homocarbonyltopsentin) is a small-molecule stem-loop RNA structure TSL2-binding compound (EC50=16.1 uM) that increases SMN2 exon 7 (E7) splicing and rescues downstream molecular alterations in SMA cells.
    PK4C9 modifies SMN2 E7 splicing in different systems, rescues functional SMN protein in SMA cells.

    Physicochemical Properties

    M.Wt 370.368
    Formula C21H14N4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (5-(1H-indole-3-carbonyl)-1H-imidazol-2-yl)(6-hydroxy-1H-indol-3-yl)methanone

    References

    1. Garcia-Lopez A, et al. Nat Commun. 2018 May 23;9(1):2032.

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