Catalog No.: PC-49646Not For Human Use, Lab Use Only.
SMN antagonist 1 (Compound 1) is a small molecule antagonist of Survival of motor neuron (SMN), preferentially binds to SMN (Kd=2.6 uM) among assayed methylarginine or methyllysine binders, disrupts the SMN-RNAP II interaction.
SMN antagonist 1 (Compound 1) is a small molecule antagonist of Survival of motor neuron (SMN), preferentially binds to SMN (Kd=2.6 uM) among assayed methylarginine or methyllysine binders, disrupts the SMN-RNAP II interaction.
SMN antagonist 1 binds tighly to methylarginine binding Tudor domains of SMN, SMNDC1, and TDRD3 than to the methyllysine binding Tudor domain of UHRF1_TTD (Kd=16 uM).
SMN antagonist 1 binds to the aromatic cage of SMN specifically.
SMN antagonist 1 disrupts SMN gene occupancy and lead to RNAP II pause, causes R-loop accumulation in HEK293 cells as detected by immunofluorescence staining.
