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Chemical Structure : SMN antagonist 1
CAS No.: 445463-11-6
Catalog No.: PC-49646Not For Human Use, Lab Use Only.
SMN antagonist 1 (Compound 1) is a small molecule antagonist of Survival of motor neuron (SMN), preferentially binds to SMN (Kd=2.6 uM) among assayed methylarginine or methyllysine binders, disrupts the SMN-RNAP II interaction.
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SMN antagonist 1 (Compound 1) is a small molecule antagonist of Survival of motor neuron (SMN), preferentially binds to SMN (Kd=2.6 uM) among assayed methylarginine or methyllysine binders, disrupts the SMN-RNAP II interaction.
SMN antagonist 1 binds tighly to methylarginine binding Tudor domains of SMN, SMNDC1, and TDRD3 than to the methyllysine binding Tudor domain of UHRF1_TTD (Kd=16 uM).
SMN antagonist 1 binds to the aromatic cage of SMN specifically.
SMN antagonist 1 disrupts SMN gene occupancy and lead to RNAP II pause, causes R-loop accumulation in HEK293 cells as detected by immunofluorescence staining.
| M.Wt | 188.27 | |
| Formula | C12H16N2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-methyl-2,3,4,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8(1H)-imine |
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1. Liu Y, et al. Nat Commun. 2022 Sep 16;13(1):5453.
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