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ML372

Chemical Structure : ML372

CAS No.: 1331745-61-9

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ML372 (ML 372)

Catalog No.: PC-62139Not For Human Use, Lab Use Only.

ML372 is a small molecule SMN modulator that increases SMN protein in patient fibroblasts with EC50 of 37 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ML372 is a small molecule SMN modulator that increases SMN protein in patient fibroblasts with EC50 of 37 nM.
    ML372 possesses good potency, pharmacokinetics, tolerance, and CNS penetration that are able to increase levels of SMN protein in several model cell lines; increase SMN protein levels in vivo.
    ML372 restores motor function, and prolong survival of SMNΔ7 SMA Mice, improves the righting reflex and extended survival of a severe mouse model of SMA.

    Physicochemical Properties

    M.Wt 360.428
    Formula C18H20N2O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(5-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)thiazol-2-yl)piperidine-4-carboxylic acid

    References

    1. Burnett BG, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

    2. Abera MB, et al. JCI Insight. 2016 Nov 17;1(19):e88427.

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