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Chemical Structure : ML372
Catalog No.: PC-62139Not For Human Use, Lab Use Only.
ML372 is a small molecule SMN modulator that increases SMN protein in patient fibroblasts with EC50 of 37 nM.
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ML372 is a small molecule SMN modulator that increases SMN protein in patient fibroblasts with EC50 of 37 nM; possesses good potency, pharmacokinetics, tolerance, and CNS penetration that are able to increase levels of SMN protein in several model cell lines; increase SMN protein levels in vivo, restore motor function, and prolong survival of SMNΔ7 SMA Mice; improves the righting reflex and extended survival of a severe mouse model of SMA.
| M.Wt | 360.428 | |
| Formula | C18H20N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Burnett BG, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
2. Abera MB, et al. JCI Insight. 2016 Nov 17;1(19):e88427.
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