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D34-919

Chemical Structure : D34-919

CAS No.: 1011641-78-3

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D34-919

Catalog No.: PC-23510Not For Human Use, Lab Use Only.

D34-919 is a small-molecule inhibitor that potently disrupts the ALDH1A3-PKM2 interaction, preventing the ALDH1A3-mediated enhancement of PKM2 tetramerization, binds to PKM2.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

D34-919 is a small-molecule inhibitor that potently disrupts the ALDH1A3-PKM2 interaction, preventing the ALDH1A3-mediated enhancement of PKM2 tetramerization, binds to PKM2.
D34-919 effectively prevents the resistance to TMZ and radiotherapy caused by overexpression of ALDH1A3 and PKM2 in N33 cells.
D34-919 enhances radio- and chemotherapy sensitivity to suppress the growth of intracranial xenograft tumors in mice.
D34-919 increases the chemoradiotherapy sensitivity of glioblastoma organoids and brain tumors in vivo.

Physicochemical Properties

M.Wt 409.55
Formula C22H27N5OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(6-(4-(tert-butyl)phenyl)-5-cyano-2-(methylthio)pyrimidin-4-yl)piperidine-4-carboxamide

References

1. Li G, et al. Cell Metab. 2024 Aug 6;36(8):1696-1710.e10.

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