| Cat. No. |
Product Name |
Information |
| PC-25624 |
LumiPK
PKL fluorescent tracer
|
LumiPK is an environment-sensitive fluorescent tracer designed to monitor allosteric binding to the liver isoform of pyruvate kinase (PKL) (λ ex=450 nm, λ em=550 nm), displays strong PKL binding with SPR KD of 37 nM. |
| PC-23510 |
D34-919
ALDH1A3-PKM2 inhibitor
|
D34-919 is a small-molecule inhibitor that potently disrupts the ALDH1A3-PKM2 interaction, preventing the ALDH1A3-mediated enhancement of PKM2 tetramerization, binds to PKM2. |
| PC-21605 |
AG-946
PKR activator
|
AG-946 (Tebapivat, AG946) is a potent, allosteric activator of wild-type and mutant RBC-specific form of pyruvate kinase (PKR) with AC50 of 5 nM for human wild-type PK, 4.3 nM and 6.9 nM for mutated K410E and R510Q PK proteins, resepctively. |
| PC-49688 |
HA344
PKM2/IMPDH inhibitor
|
HA344 (HA 344) is a dual covalent inhibitor of pyruvate kinase M2 (PKM2) and inosine monophosphate dehydrogenase (IMPDH), efficiently inhibits cutaneous metastatic melanoma (CMM). |
| PC-38586 |
ML202
PKM2 activator
|
ML202 (CID-44246498) is a highly specific, allosteric activator for the tumor-specific isoform of human pyruvate kinase M2 (PKM2) with EC50 value of 73 nM, inactive against hPyk-M1, -R, and -L isoforms. |
| PC-72959 |
Etavopivat
PKR activator
|
Etavopivat (FT-4202) is a selective, allosteric, oral RBC pyruvate kinase (PKR) activator that decreases 2,3-DPG levels and hence would increase the HbS O2 affinity to reduce sickling. |
| PC-38268 |
NPD10084
PKM2 inhibitor
|
NPD10084 (NPD 10084) is a novel compound that targets pyruvate kinase muscle isoform 2 (PKM2), exerts anti-proliferative activity against colorectal cancer cells in vitro (IC50=0.8-1.9 uM) and in vivo. |
| PC-43151 |
Mitapivat
Pyruvate kinase activator
|
Mitapivat (PKM2 activator 1020, AG-348) is a first-in-class, allosteric activator of Pyruvate kinase (PK) with mean AC50 of 29 nM (PK-R), activates a spectrum of recombinant mutant PK-R enzymes (R532W, R510Q). |
| PC-45505 |
TEPP-46
PKM2 activator
|
TEPP-46 (ML265) is a potent activator of PKM2 (pyruvate kinase M2) with IC50 of 92 nM. |
| PC-45611 |
DASA-58
PKM2 activator
|
DASA-58 (DASA58) is a potent activator of PKM2 (pyruvate kinase M2) with AC50 of 38 nM, shows no activity on PKM1 in vitro. |
| PC-26938 |
NCGC00188636
Pyruvate kinase inhibitor
|
NCGC00188636 (DBS) is a covalent inhibitor of pyruvate kinase (PYK) with IC50 of Leishmania mexicana PYK (LmPYK), inhibits both HsRPYK (the human PYK isoenzyme present in erythrocytes) and HsM2PYK (the human PYK isoenzyme present in embryonic and tumour cells) with IC50 values of 8 uM and 16.3 uM, respectively. |
| PC-26756 |
SNH-119014
Pyruvate kinase activator
|
SNH-119014 is a novel allosteric Pyruvate kinase (PK) activator with AC50 of 28.9 nM for recombinant human PKLR, Emax of 949.9%. |
