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Chemical Structure : Etavopivat
CAS No.: 2245053-57-8
Catalog No.: PC-72959Not For Human Use, Lab Use Only.
Etavopivat (FT-4202) is a novel oral activator of PKR that decreases 2,3-DPG levels and hence would increase the HbS O2 affinity to reduce sickling.
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Etavopivat (FT-4202) is a novel oral activator of PKR that decreases 2,3-DPG levels and hence would increase the HbS O2 affinity to reduce sickling.
FT-4202 increases the hemoglobin S O2 affinity to reduce sickling and improve RBC membrane deformability.
Etavopivat (FT-4202) increased Hb-oxygen affinity and reduced sickling under deoxygenation in ex vivo RBCs from donors with sickle cell disease (SCD).
Oral administration of FT-4202 increases Hb and improves RBC parameters in BERK mice.
Etavopivat is currently being evaluated in clinical trials for the treatment sickle cell disease (SCD).
| M.Wt | 457.501 | |
| Formula | C22H23N3O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2S)-1-(5-(2,3-Dihydro(1,4)dioxino(2,3-b)pyridine-7- sulfonyl)-3,4,5,6-tetrahydropyrrolo(3,4-C)pyrrol-2(1H)- YL)-3-hydroxy-2-phenylpropan-1-one |
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1. Shrestha A, et al. Blood Adv. 2021 May 11;5(9):2385-2390.
2. Forsyth S, et al. Clin Pharmacol Drug Dev. 2022 Jan 12.
3. Schroeder P, et al. J Pharmacol Exp Ther. 2022 Mar;380(3):210-219.
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