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Chemical Structure : Mitapivat
CAS No.: 1260075-17-9
Catalog No.: PC-43151Not For Human Use, Lab Use Only.
Mitapivat (PKM2 activator 1020, AG-348) is a first-in-class, allosteric activator of Pyruvate kinase (PK) with mean AC50 of 29 nM (PK-R), activates a spectrum of recombinant mutant PK-R enzymes (R532W, R510Q).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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Mitapivat (PKM2 activator 1020, AG-348) is a first-in-class, allosteric activator of Pyruvate kinase (PK) with mean AC50 of 29 nM (PK-R), activates a spectrum of recombinant mutant PK-R enzymes (R532W, R510Q).
AG-348 can increase the activity of wild-type and mutant PK enzymes in biochemical assays and in patient red blood cells treated ex vivo.
AG-348 demonstrates enhanced glycolytic pathway activity in PK-deficient RBCs that contain a variety of mutations.
| M.Wt | 450.5533 | |
| Formula | C24H26N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
8-Quinolinesulfonamide, N-[4-[[4-(cyclopropylmethyl)-1-piperazinyl]carbonyl]phenyl]- |
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1. Qi W, et al. Nat Med. 2017 Jun;23(6):753-762.
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