SNH-119014 | Pyruvate kinase activator

Chemical Structure : SNH-119014

SNH-119014 (SNH119014)

Catalog No.: PC-26756Not For Human Use, Lab Use Only.

SNH-119014 is a novel allosteric Pyruvate kinase (PK) activator with AC50 of 28.9 nM for recombinant human PKLR, Emax of 949.9%.

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Biological Activity

SNH-119014 is a novel allosteric Pyruvate kinase (PK) activator with AC50 of 28.9 nM for recombinant human PKLR, Emax of 949.9%.
SNH-119014 increases the activity of PKLR and ATP levels in Red Blood Cell (RBC) to an extent comparable to AG-348.
SNH-119014 increased ATP levels, reduced ROS, and improved the GSH/GSSG ratio in erythroid precursors.

Physicochemical Properties

M.Wt	435.45
Formula	C20H19F2N3O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(2,4-difluorophenyl)-3-hydroxy-1-(1'-(pyridin-2-ylsulfonyl)-1',4'-dihydro-2H,2'H-[3,3'-biazetylidene]-1(4H)-yl)propan-1-one

References

1. Huang Q, et al. Front Pharmacol. 2026 Apr 23;17:1719328.

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SNH-119014 (SNH119014)

Biological Activity

Physicochemical Properties

References

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