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Chemical Structure : ML202
CAS No.: 1221186-52-2
Catalog No.: PC-38586Not For Human Use, Lab Use Only.
ML202 (CID-44246498) is a highly specific, allosteric activator for the tumor-specific isoform of human pyruvate kinase M2 (PKM2) with EC50 value of 73 nM, inactive against hPyk-M1, -R, and -L isoforms.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $348 | In stock | |
| 50 mg | $548 | In stock | |
| 100 mg | Get quote |
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ML202 (CID-44246498) is a highly specific, allosteric activator for the tumor-specific isoform of human pyruvate kinase M2 (PKM2) with EC50 value of 73 nM, inactive against hPyk-M1, -R, and -L isoforms.
ML202 affects the cooperativity of phosphoenolpyruvate (PEP) binding to PKM2, with little affect on adenosine diphosphate (ADP) binding, in a manner similar to Fructose-1,6-bisphosphate (FBP).
| M.Wt | 387.472 | |
| Formula | C18H17N3O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4,6-Dihydro-6-[(3-methoxyphenyl)methyl]-4-methyl-2-(methylsulfinyl)-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one |
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1. Matthew B Boxer, et al. Bethesda (MD): National Center for Biotechnology Information (US); 2010–.
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