Chemical Structure : TEPP-46
CAS No.:
1221186-53-3
TEPP-46
(ML265, TEPP46, ML-265)
Catalog No. : PC-45505Not For Human Use, Lab Use Only.
TEPP-46 (ML265) is a potent activator of PKM2 (pyruvate kinase M2) with IC50 of 92 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4550501
Biological Activity
TEPP-46 (ML265) is a potent activator of PKM2 (pyruvate kinase M2) with IC50 of 92 nM.
Physicochemical Properties
M.Wt
372.4645
Formula
C17H16N4O2S2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 28 mg/mL
Chemical Name/SMILES
5H-Thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one, 6-[(3-aminophenyl)methyl]-4,6-dihydro-4-methyl-2-(methylsulfinyl)-
References
1. Anastasiou D, et al. Nat Chem Biol.
2. Qi W, et al. Nat Med.
3. Witney TH, et al. Sci Transl Med.
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