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DASA-58

Chemical Structure : DASA-58

CAS No.: 1203494-49-8

DASA-58 (DASA58, DASA 58)

Catalog No.: PC-45611Not For Human Use, Lab Use Only.

A potent activator of PKM2 (pyruvate kinase M2) with AC50 of 38 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

DASA-58 is a potent activator of PKM2 (pyruvate kinase M2) with AC50 of 38 nM; shows no activity on PKM1 in vitro.
DASA-58 binds to PKM2 at the subunit interaction interface site that is distinct from that of the endogenous activator FBP.
DASA-58 inhibits LPS-induced HIF-1α and IL-1β, as well as the expression of a range of other HIF-1α-dependent genes.

Physicochemical Properties

M.Wt 453.5324
Formula C19H23N3O6S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 35 mg/mL

Chemical Name/SMILES

Benzenamine, 3-[[4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]hexahydro-1H-1,4-diazepin-1-yl]sulfonyl]-

References

1. Anastasiou D, et al. Nat Chem Biol. 2012 Oct;8(10):839-47.

2. Palsson-McDermott EM, et al. Cell Metab. 2015 Jan 6;21(1):65-80.

3. Giannoni E, et al. Oncotarget. 2015 Sep 15;6(27):24061-74.

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