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Chemical Structure : DASA-58
CAS No.: 1203494-49-8
Catalog No.: PC-45611Not For Human Use, Lab Use Only.
A potent activator of PKM2 (pyruvate kinase M2) with AC50 of 38 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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DASA-58 is a potent activator of PKM2 (pyruvate kinase M2) with AC50 of 38 nM; shows no activity on PKM1 in vitro.
DASA-58 binds to PKM2 at the subunit interaction interface site that is distinct from that of the endogenous activator FBP.
DASA-58 inhibits LPS-induced HIF-1α and IL-1β, as well as the expression of a range of other HIF-1α-dependent genes.
| M.Wt | 453.5324 | |
| Formula | C19H23N3O6S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 35 mg/mL |
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| Chemical Name/SMILES |
Benzenamine, 3-[[4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]hexahydro-1H-1,4-diazepin-1-yl]sulfonyl]- |
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1. Anastasiou D, et al. Nat Chem Biol. 2012 Oct;8(10):839-47.
2. Palsson-McDermott EM, et al. Cell Metab. 2015 Jan 6;21(1):65-80.
3. Giannoni E, et al. Oncotarget. 2015 Sep 15;6(27):24061-74.
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