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DANA

Chemical Structure : DANA

CAS No.: 24967-27-9

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DANA (Neu5Ac2en, 2,3-dehydro-2-deoxy-N-acetylneuraminic acid)

Catalog No.: PC-28384Not For Human Use, Lab Use Only.

DANA (Neu5Ac2en, 2,3-dehydro-2-deoxy-N-acetylneuraminic acid) is a potent Neuraminidas isoenyzmes (Sialidases, NEU) inhibitor with IC50 of 49, 43, 7.7, and 8.3 uM for NEU1, NEU2, NEU3, and NEU4, respectively, shows anti-influenza virus activity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

DANA (Neu5Ac2en, 2,3-dehydro-2-deoxy-N-acetylneuraminic acid) is a potent Neuraminidase isoenyzmes (Sialidases, NEU) inhibitor with IC50 of 49, 43, 7.7, and 8.3 uM for NEU1, NEU2, NEU3, and NEU4, respectively, shows anti-influenza virus activity.

Physicochemical Properties

M.Wt 291.25
Formula C11H17NO8
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2R,3R,4S)-3-acetamido-4-hydroxy-2-((1R,2R)-1,2,3-trihydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylic acid

References

1. Xiao A, et al. ACS Catal. 2018;8(1):43-47.

2. Magesh S, et al. Bioorg Med Chem Lett. 2008;18(2):532-537.

3. Tianlin Guo, et al. J Med Chem. 2018 Dec 27;61(24):11261-11279.

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